What If The Secret To Youthful Skin, Brain Health, And Longevity… Was Oxygen?
Imagine reversing inflammation, rebuilding your microbiome, extending your life, and glowing from head to toe—all by lying in a pressurised oxygen chamber. Biohacker and Blueprint founder Bryan Johnson swears by it. And his Hyperbaric Oxygen Therapy (HBOT) protocol isn’t just changing his life—it could save yours too.
In this post, we unpack the jaw-dropping science, results, and long-tail search questions around HBOT therapy, air pollution damage, and why this protocol could become the biggest anti-aging and brain-boosting secret of 2025.
What Is Hyperbaric Oxygen Therapy (HBOT)?
Hyperbaric Oxygen Therapy (HBOT) is a medical-grade treatment that involves breathing 100% pure oxygen in a pressurized chamber. It allows the body to absorb dramatically more oxygen than normal—up to 15x more than breathing room air.
Think of it like a reset button for your cells. HBOT creates a short burst of oxidative stress, prompting the body to repair, regenerate, and rebuild itself more efficiently.
Bryan Johnson’s HBOT Protocol: The Details
Bryan underwent a rigorous 90-day HBOT protocol designed for longevity and performance, not just recovery. His exact setup:
- Chamber Pressure: 2.0 ATA (Atmospheres Absolute) – the gold standard for deep tissue oxygenation
- Oxygen Source: 100% medical-grade oxygen (not concentrators)
- Duration: 60 sessions in 90 days
- Each Session: 90 minutes with 20 mins oxygen on / 5 mins off (to create hypoxic signaling)
- Frequency: ~5x per week with 2 rest days
- Mask Use: Oxygen via mask (not ambient) to avoid risks like cataracts
“It’s been the most efficacious therapy we’ve done since starting Blueprint,” Bryan said.
The Results: Why HBOT Could Be Revolutionary
Bryan’s post-therapy results were nothing short of staggering:
| Health Marker | Before | After |
|---|---|---|
| Systemic Inflammation (hs-CRP) | Low | Undetectable |
| Acromansia (gut bacteria) | — | ↑ 1000% |
| Short-Chain Fatty Acids | — | ↑ 250–290% |
| Dementia Marker | — | ↓ 28.6% |
| Skin Elasticity | — | ↑ 144% |
| Telomere Length | — | Increased (a marker of longevity) |
He even coined the term “HBOT Skin” to describe the rejuvenation. Forget fillers—this is cellular-level skin regeneration.
Why Oxygen Therapy Matters In 2025 (Especially If You’re Breathing City Air)
During his travels to India and China, Bryan experienced dangerous levels of PM2.5 air pollution—comparable to inhaling 3–5 cigarettes a day. This fine particulate matter is so small, it enters your bloodstream, lungs, and brain.
In comparison, HBOT floods the body with healing oxygen. One fights death, the other breathes life.
Curious About HBOT? Here’s What People Are Asking in 2025
What is hyperbaric oxygen therapy good for?
Hyperbaric oxygen therapy is good for reducing inflammation, accelerating wound healing, regenerating skin, improving gut health, supporting brain function, and even promoting telomere lengthening. It’s becoming a go-to for biohackers, longevity seekers, and athletes alike.
Is HBOT safe for long-term use?
Yes, when done correctly using medical-grade equipment and supervised protocols like Bryan Johnson’s 60-session HBOT regimen, it’s considered safe. However, too frequent or poorly administered sessions may lead to oxidative stress—so protocol precision matters.
Bryan Johnson hyperbaric chamber results
From undetectable inflammation levels to a 1000% microbiome boost, skin rejuvenation, and a 28.6% reduction in dementia markers—Bryan Johnson’s hyperbaric oxygen chamber results are some of the most impressive ever documented in the self-quantified wellness world.
How to reverse inflammation naturally
Alongside HBOT, reversing inflammation naturally involves a clean anti-inflammatory diet, regular movement, air detox, supplementing with antioxidants (like NAC or glutathione), and removing sugar and seed oils.
Best biohacking therapies 2025
Some of the best biohacking therapies for 2025 include:
Hyperbaric oxygen therapy (HBOT)
NAD+ infusions
Cold plunges
Red light therapy
Precision probiotics (like Akkermansia boosters)
How to improve air quality at home
Use HEPA or IQAir filters, switch your HVAC to MERV-13 filters, and monitor PM2.5 levels with an air quality tracker. This is one of the best ways to protect your lungs, brain, and skin daily.
HBOT for skin glow
HBOT isn’t just internal—it’s your whole-body facial. Bryan Johnson called it “the best skin remodeling therapy in the world” thanks to boosted collagen, elastin, and blood flow.
Hyperbaric oxygen for anti-aging
HBOT for anti-aging is gaining traction in longevity circles. It extends telomeres, reduces oxidative stress, improves mitochondrial function, and may help reverse biological age markers.
Longevity protocols 2025
The top longevity protocols for 2025 include Bryan Johnson’s Blueprint HBOT, low-carb Mediterranean diets, resistance training, air detoxification, and advanced biomarker tracking.
How to detox from pollution exposure
To detox from pollution exposure: install air filters, avoid exercising outdoors during high PM2.5 days, eat antioxidant-rich foods, and supplement with glutathione or NAC. HBOT also helps oxygenate tissues damaged by environmental stress.
Don’t Have a Chamber? Here’s What You Can Do
If you can’t access a high-pressure HBOT clinic, here’s how to support your air and oxygen health today:
At-Home Air Detox Protocol:
- Use an IQAir or Dyson air purifier
- Install MERV-13 filters in your HVAC system
- Monitor your air with an indoor quality tracker
- Avoid outdoor exercise if PM2.5 > 70
- Wear an N95 mask during high-pollution days
Supplements That Help:
- N-Acetylcysteine (NAC) – fights oxidative damage
- Glutathione – supports detoxification
- Omega-3s – reduces inflammation
- Quercetin & Curcumin – anti-inflammatory powerhouses
Final Word: Should You Try It?
If you’re serious about living longer, looking younger, and feeling mentally sharper, HBOT may be one of the most underrated tools out there. While research is still emerging, Johnson’s Blueprint protocol is pioneering what the future of wellness could look like.
It’s not just a treatment—it’s a revolution.
Related Reading on StephiLaReine.com:
- Best Biohacking Tools For Women in 2025
- How To Reverse Inflammation With Food
- The Air Detox Plan For Urban Wellness
- Everything You Need To Know About NAD+ And Anti-Aging
References
- Hadanny A, et al. (2020). Hyperbaric oxygen therapy can induce neuroplasticity and telomere lengthening in humans. Aging, 12(22), 22445–22456. https://doi.org/10.18632/aging.202188
- Bryan Johnson’s Blueprint Protocol – Personal biohacking journey and quantified research via https://blueprint.bryanjohnson.com
- American College of Hyperbaric Medicine – Overview on clinical uses of HBOT. https://achm.org
- NIH National Library of Medicine – “Hyperbaric Oxygen Therapy: An Overview.” https://pubmed.ncbi.nlm.nih.gov/
- IQAir World Air Quality Index – Real-time PM2.5 tracking and pollution impacts. https://www.iqair.com/world-air-quality
Stephi LaReine is a multi-award-winning Liverpool UK based content creator, journalist and influencer and digital storyteller. Since launching stephilareine.com in 2014, she has written over a thousand articles spanning fashion, beauty, health, lifestyle, and conscious travel. With a background in trend forecasting, neurodivergent advocacy, and longevity research, Stephi brings a unique lens to every post—blending scientific insight with a soulful, poetic voice.
She’s collaborated with leading global brands and has been featured across fashion week panels, travel campaigns, and health optimization forums.
Her content is rooted in lived experience, personal curiosity, and a relentless drive to empower women to take up space, explore the world boldly, and live longer, more radiant lives. Every article is a step toward building a kinder, smarter, more colourful world.
✨ Follow more stories, insights, and behind-the-scenes on Instagram @stephilareine and stephilareine.com.